Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.
Identifieur interne : 002B85 ( Main/Exploration ); précédent : 002B84; suivant : 002B86Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.
Auteurs : Lili Xu [République populaire de Chine] ; Yanfang Zhang [République populaire de Chine] ; Yun Liu [République populaire de Chine] ; Zhiwei Chen ; Hongkui Deng [République populaire de Chine] ; Zhongbin Ma [République populaire de Chine] ; Hualin Wang [République populaire de Chine] ; Zhihong Hu [République populaire de Chine] ; Fei Deng [République populaire de Chine]Source :
- The Journal of general virology [ 1465-2099 ] ; 2009.
Descripteurs français
- KwdFr :
- Alignement de séquences, Analyse de séquence d'ADN, Animaux, Attachement viral, Cellules HeLa, Chiens viverrins, Clonage moléculaire, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (métabolisme), Humains, Liaison aux protéines, Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Phylogénie, Protéines de l'enveloppe virale (métabolisme), Pénétration virale, Récepteurs viraux (métabolisme), Similitude de séquences d'acides aminés, Séquence d'acides aminés, Virus du SRAS (physiologie).
- MESH :
- génétique : Peptidyl-Dipeptidase A.
- métabolisme : Glycoprotéines membranaires, Peptidyl-Dipeptidase A, Protéines de l'enveloppe virale, Récepteurs viraux.
- physiologie : Virus du SRAS.
- Alignement de séquences, Analyse de séquence d'ADN, Animaux, Attachement viral, Cellules HeLa, Chiens viverrins, Clonage moléculaire, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Humains, Liaison aux protéines, Phylogénie, Pénétration virale, Similitude de séquences d'acides aminés, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Cloning, Molecular, HeLa Cells, Humans, Membrane Glycoproteins (metabolism), Molecular Sequence Data, Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Phylogeny, Protein Binding, Raccoon Dogs, Receptors, Virus (metabolism), SARS Virus (physiology), Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (metabolism), Virus Attachment, Virus Internalization.
- MESH :
- chemical , genetics : Peptidyl-Dipeptidase A.
- chemical , metabolism : Membrane Glycoproteins, Peptidyl-Dipeptidase A, Receptors, Virus, Viral Envelope Proteins.
- physiology : SARS Virus.
- Amino Acid Sequence, Animals, Cloning, Molecular, HeLa Cells, Humans, Molecular Sequence Data, Phylogeny, Protein Binding, Raccoon Dogs, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Spike Glycoprotein, Coronavirus, Virus Attachment, Virus Internalization.
Abstract
Raccoon dog is one of the suspected intermediate hosts of severe acute respiratory syndrome coronavirus (SARS-CoV). In this study, the angiotensin-converting enzyme 2 (ACE2) gene of raccoon dog (rdACE2) was cloned and sequenced. The amino acid sequence of rdACE2 has identities of 99.3, 89.2, 83.9 and 80.4 % to ACE2 proteins from dog, masked palm civet (pcACE2), human (huACE2) and bat, respectively. There are six amino acid changes in rdACE2 compared with huACE2, and four changes compared with pcACE2, within the 18 residues of ACE2 known to make direct contact with the SARS-CoV S protein. A HeLa cell line stably expressing rdACE2 was established; Western blot analyses and an enzyme-activity assay indicated that the cell line expressed ACE2 at a similar level to two previously established cell lines that express ACE2 from human and masked palm civet, respectively. Human immunodeficiency virus-backboned pseudoviruses expressing spike proteins derived from human SARS-CoV or SARS-CoV-like viruses of masked palm civets and raccoon dogs were tested for their entry efficiency into these cell lines. The results showed that rdACE2 is a more efficient receptor for human SARS-CoV, but not for SARS-CoV-like viruses of masked palm civets and raccoon dogs, than huACE2 or pcACE2. This study provides useful data to elucidate the role of raccoon dog in SARS outbreaks.
DOI: 10.1099/vir.0.013490-0
PubMed: 19625462
Affiliations:
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sortKey="Xu, Lili" sort="Xu, Lili" uniqKey="Xu L" first="Lili" last="Xu">Lili Xu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Yanfang" sort="Zhang, Yanfang" uniqKey="Zhang Y" first="Yanfang" last="Zhang">Yanfang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Zhiwei" sort="Chen, Zhiwei" uniqKey="Chen Z" first="Zhiwei" last="Chen">Zhiwei Chen</name><affiliation><nlm:affiliation>AIDS Institute, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong SAR.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong SAR</wicri:noCountry></affiliation></author><author><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><affiliation wicri:level="4"><nlm:affiliation>Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Ma, Zhongbin" sort="Ma, Zhongbin" uniqKey="Ma Z" first="Zhongbin" last="Ma">Zhongbin Ma</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Hualin" sort="Wang, Hualin" uniqKey="Wang H" first="Hualin" last="Wang">Hualin Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Deng, Fei" sort="Deng, Fei" uniqKey="Deng F" first="Fei" last="Deng">Fei Deng</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cloning, Molecular</term><term>HeLa Cells</term><term>Humans</term><term>Membrane Glycoproteins (metabolism)</term><term>Molecular Sequence Data</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Phylogeny</term><term>Protein Binding</term><term>Raccoon Dogs</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (physiology)</term><term>Sequence Alignment</term><term>Sequence Analysis, DNA</term><term>Sequence Homology, Amino Acid</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Envelope Proteins (metabolism)</term><term>Virus Attachment</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Attachement viral</term><term>Cellules HeLa</term><term>Chiens viverrins</term><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Phylogénie</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Pénétration virale</term><term>Récepteurs viraux (métabolisme)</term><term>Similitude de séquences d'acides aminés</term><term>Séquence d'acides aminés</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term><term>Peptidyl-Dipeptidase A</term><term>Receptors, Virus</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Peptidyl-Dipeptidase A</term><term>Protéines de l'enveloppe virale</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cloning, Molecular</term><term>HeLa Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Protein Binding</term><term>Raccoon Dogs</term><term>Sequence Alignment</term><term>Sequence Analysis, DNA</term><term>Sequence Homology, Amino Acid</term><term>Spike Glycoprotein, Coronavirus</term><term>Virus Attachment</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Attachement viral</term><term>Cellules HeLa</term><term>Chiens viverrins</term><term>Clonage moléculaire</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Liaison aux protéines</term><term>Phylogénie</term><term>Pénétration virale</term><term>Similitude de séquences d'acides aminés</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Raccoon dog is one of the suspected intermediate hosts of severe acute respiratory syndrome coronavirus (SARS-CoV). In this study, the angiotensin-converting enzyme 2 (ACE2) gene of raccoon dog (rdACE2) was cloned and sequenced. The amino acid sequence of rdACE2 has identities of 99.3, 89.2, 83.9 and 80.4 % to ACE2 proteins from dog, masked palm civet (pcACE2), human (huACE2) and bat, respectively. There are six amino acid changes in rdACE2 compared with huACE2, and four changes compared with pcACE2, within the 18 residues of ACE2 known to make direct contact with the SARS-CoV S protein. A HeLa cell line stably expressing rdACE2 was established; Western blot analyses and an enzyme-activity assay indicated that the cell line expressed ACE2 at a similar level to two previously established cell lines that express ACE2 from human and masked palm civet, respectively. Human immunodeficiency virus-backboned pseudoviruses expressing spike proteins derived from human SARS-CoV or SARS-CoV-like viruses of masked palm civets and raccoon dogs were tested for their entry efficiency into these cell lines. The results showed that rdACE2 is a more efficient receptor for human SARS-CoV, but not for SARS-CoV-like viruses of masked palm civets and raccoon dogs, than huACE2 or pcACE2. This study provides useful data to elucidate the role of raccoon dog in SARS outbreaks.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li><li>Pékin</li></region><settlement><li>Pékin</li><li>Wuhan</li></settlement><orgName><li>Université de Pékin</li></orgName></list><tree><noCountry><name sortKey="Chen, Zhiwei" sort="Chen, Zhiwei" uniqKey="Chen Z" first="Zhiwei" last="Chen">Zhiwei Chen</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Xu, Lili" sort="Xu, Lili" uniqKey="Xu L" first="Lili" last="Xu">Lili Xu</name></region><name sortKey="Deng, Fei" sort="Deng, Fei" uniqKey="Deng F" first="Fei" last="Deng">Fei Deng</name><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><name sortKey="Liu, Yun" sort="Liu, Yun" uniqKey="Liu Y" first="Yun" last="Liu">Yun Liu</name><name sortKey="Ma, Zhongbin" sort="Ma, Zhongbin" uniqKey="Ma Z" first="Zhongbin" last="Ma">Zhongbin Ma</name><name sortKey="Wang, Hualin" sort="Wang, Hualin" uniqKey="Wang H" first="Hualin" last="Wang">Hualin Wang</name><name sortKey="Zhang, Yanfang" sort="Zhang, Yanfang" uniqKey="Zhang Y" first="Yanfang" last="Zhang">Yanfang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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